Ministered to Sheep in the Late Transition Period on Immune and Metabolic Values and Passive Immunity in Lambs

Şemistan KIZILTEPE; Erdoğan UZLU

doi:10.5281/zenodo.19218341

Yazarlar

Şemistan KIZILTEPE Igdır University, Tuzluca Vocational School, Igdır https://orcid.org/0000-0003-3727-8893
Erdoğan UZLU Balıkesir University, Faculty of Veterinary Medicine, Department of Veterinary Internal Diseases, Balıkesir https://orcid.org/0000-0002-3064-6633

DOI:

https://doi.org/10.5281/zenodo.19218341

Anahtar Kelimeler:

Levamisole, Akkaraman crossbred, Transition period, Passive immunity, Metabolic profile

Özet

This study aimed to investigate the effects of levamisole administration during the late gestation period in ewes on immune and metabolic parameters during the transition period and on passive immunity in lambs. For this purpose, 60 Akkaraman crossbred ewes with similar characteristics were divided into two groups: Levamisole (Group I, n = 30) and Control (Group II, n = 30). Starting from the 15th week of gestation until parturition, Group I received levamisole at a dose of 2.5 mg/kg subcutaneously on a weekly basis, while Group II was administered a placebo (physiological saline). Blood samples were collected from the ewes before treatment, during the 16th, 17th, and 18th weeks of gestation, within the first 4 hours after parturition, and during the 3rd week of lactation; samples from lambs were obtained within 24–36 hours after birth. Analysis of parameters (GLU, NEFA, BHB, IgG, ALT, AST, etc.) revealed statistically significant differences (P < 0.05) between groups in LDL and IgG levels in ewes. In lambs, LDL, TP, GGT, and IgG levels differed significantly between groups. These findings indicate that levamisole administration during late gestation may have beneficial effects on maternal health and passive immunity transfer in lambs.

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Ministered to Sheep in the Late Transition Period on Immune and Metabolic Values and Passive Immunity in Lambs

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